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What is NEPHROTIC SYNDROME?

Posted on October 23, 2014 | No Comments on What is NEPHROTIC SYNDROME?

Nephrotic Syndrome is a clinical disorder characterized by:

  • Marked increase in protein in the urine (proteinuria);
  • Decrease in albumin in the blood (hypoalbuminemia);
  • Edema; and
  • Hyperlipidemia
Causes: Chronic Glomerulonephritis, Diabetes Mellitus, SLE (systemic lupus erythematosus)
Clinical Manifestations:
a. slow onset of fluid retention hat progressees to pitting edema
b. Hematuria, urinary casts
Management.
  • Control edema
    • Follow a sodium-restricted diet
    • Use diuretics to block aldosterone formation
    • Administer salt (poor albumin)
  • Provide a high-protein diet (to restore body proteins) and a high-calorie diet
  • Bed rest to promote diuresis and reduce the edema
  • Medication therapy: ACE inibitors to reduce protein loss; NSAIDS and Prednisone to reduce proteinuria, penicillin or broad spectrum antibiotic to indicate bacteria

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